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When estradiol levels start to decline as women age or they transit to menopause, the protective effect of estradiol is lost (210)
These outcomes lead to the remodeling of the extracellular matrix, oxidative stress, inflammation, cardiomyocyte apoptosis, fibrosis, and metabolic abnormalities [55]
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Semaglutide is not recommended for people who already have gastroparesis
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